Research on the generation and utilization of the phenomena produced by molecular interaction, such as electric, optic, heat, magnesium and the distribution gradient of molecules, to sensing or detecting the properties and quantities of molecules, resulting devices or sensors based on the principles, and further miniaturization of the devices. The final goal of the research is to develop key parts or even instruments for chemical analysis; Study on sample pre-treatment method and technologies with high selectivity and high enrichment factor, leading to practical devices; Utilizing modern analytical instrumentations and technologies for the separation and analysis of complex and trace amount of organic compounds in natural products, petrochemical industries and environmental samples.